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Mar-Apr 2011;77(2):128-134

Deleterious off-target effects in women 10 years or more past menopause, such as ovarian, endometrial, and breast cancers, intravascular thrombosis, cardiovascular episodes, and stroke, and suppression of endogenous testosterone and libido and increased risk of prostate cancer in men, have precluded broad clinical applications (Stevenson and Thornton, 2007)

Among the collected studies, 25 studies met the aforementioned criteria

Environ Chem Lett 17:11951208 Gaur JP, Rai LC (2001) Heavy metal tolerance in algae

mTORC1 activity is enabled by the binding of its subunit Raptor to Rag proteins on the lysosome, as part of its nutrient-sensing functions 7,8

Picardi A, de Oliveira AC, Muguerza B, Tosar A, Quiroga J, Castilla-Cortazar I, Santidrian S, Prieto J: Low doses of insulin-like growth factor-I improve nitrogen retention and food efficiency in rats with early cirrhosis