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doi: 10.1016/j.cmet.2020.06.010 139 KernanK

Studies show that thiamine deficiency further inhibits PDH activity, accelerates M1 polarization, and exacerbates experimental colitis [452], while lactate dehydrogenase inhibitors can block this vicious cycle and partially restore immune homeostasis [452]

Sterlin D, Mathian A, Miyara M, Mohr A, Anna F, Clar L et al

1 g of peptides were separated on a 50 cm length 75 m internal diameter (ID) C18 Pepmap Acclaim column (Thermo Fisher) using a linear 90-minute acetonitrile gradient