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Moreover, SQSTM/p62 is a poly-ubiquitin-binding protein that is degraded via autophagy [99]

doi: 10.1016/j.pbi.2011.07.014 83 SwansonS.GilroyS

Given that hsa-miR-146a and hsa-miR-155 regulate inflammatory pathways, these data support an epigenetic mechanism by which chronic inflammation contributes to the pathophysiology of depression