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Athletes involved in sports that put a lot of pressure on the knees, such as long-distance running, may be at higher risk for osteoarthritis of the knee

Moreover, the cytokine signatures have potential as biomarkers to differentiate the two types of IBD as CD primarily expresses Th1- and Th17-associated cytokines (IL-17, -23 and -32), whereas UC is an atypical Th2-with low IL-4 and high IL-5, -13, -15 and -33 [70]

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However, the Bcl-2/Bax ratio, which was up-regulated in the ATF4-overexpressing cells, was SIRT1-independent, suggesting that SIRT1-independent mechanisms also play a role in the ATF4-induced MDR in gastric cancer cells