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It also enhances the absorption of glutathione into cells, increasing its effectiveness

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Comment: The applicant submitted a response to our concerns that some components or parts of the aprevo Cervical ACDF System, specifically the aprevo insertion instrument, the integrated fixation screws, and/or the CAM, may be considered a material or supply furnished incident to the service, because, as previously discussed with respect to criteria at 419.66(b)(3), it is unclear how and when these components or parts are used, and whether they can be substituted with other products

However, excessive copper accumulation leads to increased ROS generation, resulting in oxidative stress and cellular damage (196)