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10.1038/srep21913 151 YuH.GongW.MeiJ.QinL.PiaoZ.YouD.et al (2022)

In addition, LDL particles vary in size and cholesterol content

The substrate-like 4-NP may not get the right position or proper proximity on the surface of the AuNP owing to the steric and electrostatic effect of the DHLA-Ala ligand, then reduction of 4-NP to 4-AP which is catalyzed by DHLA-Ala@AuNPs can be slower than DHLA@AuNPs

The future studies will further identify, verify the effectiveness of the peptides among different population, develop best clinical standard operating procedures for application of peptides in a personalized approach and clinical trials for establishing its health effects (62, 70)