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Furthermore, the ethical constraints of testing novel therapies in pregnant populations, given potential fetal harm, limit the available translational pathways, exacerbating the gap between preclinical promise and clinical application [68]

Immunohistochemistry of brain tissues from mice treated with GHK showed evidence of decreased inflammation and increased labeling of histone deacetylase 2, suggesting that in addition to an anti-inflammatory effect, GHK may be triggering an epigenetic pathway in the amelioration of cognitive impairment in aging mice

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The components of glutamine metabolism, including metabolic enzymes, metabolites, and metabolite transporters, demonstrate high sensitivity and specificity in diagnosis, relapse monitoring, and stage prediction

19 (5), e202100987