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Insights on the use of alpha-lipoic acid for therapeutic purposes

GTP-bound RhoA activates ROK, which phosphorylates and thereby inhibits MLCP, enhancing MLC phosphorylation mediated by myosin light chain kinase (MLCK), and ultimately promoting smooth muscle contraction (Kimura et al., 1996)

Ann Surg 200:405-412, 1984

At 3 h, more than 50% of the DEGs changed by at least 2-fold in hpr1 ( p adj 1) are already restored to Col-0 expression patterns by deficient GLYR1 (Supplementary Fig