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Most exported proteins contain a signal sequence for entry into the endoplasmic reticulum (ER) followed by 1530 residues and a motif Plasmodium export element (PEXEL)/vacuolar transport signal 6,7

In this regard, as 15LO1 increased, GPX4 expression concomitantly increased to balance the high 15LO1 activity (Figure 2C)

doi: 10.3389/fcimb.2022.959793 95 Al-NasirySAmbrosinoESchlaepferMMorrSAWietenLVonckenJWet al

Dimitrow PP, Rajtar-Salwa R (2016): Obstructive Form of Hypertrophic Cardiomyopathy-Left Ventricular Outflow Tract Gradient: Novel Methods of Provocation, Monitoring of Biomarkers, and Recent Advances in the Treatment

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Moreover, the decreased mucociliary clearance in the respiratory tract, combined to the defective ion transport allows the proliferation of Pseudomonas aeruginosa as well as other pathogens in the respiratory tract which become more and more resistant due to iterative treatments and result in a repetitive inflammatory response (114)