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Moreover, DHA-enriched diets alleviate NAFLD-associated characteristics and ferroptosis-induced hepatic injury in zebrafish

However, HDAC6 inhibitors are poorly soluble in water which restricts their bioavailability and BBB permeability

The challenges in targeting KRAS stem from its biological characteristics, such as a smooth surface lacking deep binding pockets and its high-affinity GTP-binding activity, which made the development of small-molecule inhibitors particularly difficult

Table 3 summarizes key nanoplatforms used in drug delivery, highlighting their advantages and limitations

[3] Additionally, glycine itself appears to have direct insulin-sensitizing properties: it stimulates glucagon-like peptide-1 (GLP-1) secretion from intestinal L-cells, activates hepatic GLP-1 receptors, and modulates bile acid composition in ways that favor improved glucose homeostasis

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