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Hypovolemia (decrease in the volume of circulating blood) is associated with rising levels of serum MMA

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The effects were attributed to decreased BBB permeability, suppression of pro-inflammatory cytokines (TNF-a and IL-6), and modulation of excitatory and inhibitory neurotransmitter signalling [151]

People with diabetes appear to be at increased risk, and the risk is increased 3-fold during pregnancy, especially in the third trimester and first week postpartum