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Iron-induced -syn aggregation can contribute to dopaminergic neurodegeneration through additional mechanisms, potentially creating a feedback loop in which -syn further enhances iron accumulation, thus perpetuating a vicious cycle of neurotoxicity

Low amounts of ROS can activate adaptive cellular machinery to increase the organisms stress resistance

Synthesis and characterization of JQ1-CA and Amide-CA can be found in Supplementary Note 1

This can be achieved by either increasing the rate by infusing over a shorter time or increasing the concentration of NAC in the final infusion

Although vitamin B 12 deficiency is known to damage the myelin sheath covering cranial, spinal, and peripheral nerves, the biochemical processes leading to neurologic damage in vitamin B 12 deficiency are not yet fully understood (22)