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Mesenchymal stem cell therapy: mechanisms and translational advances of Multi-Source MSCs in ovarian regeneration MSC-Based Therapy for POI: From Experimental Proof to Translational Promise Research exploring MSCs as a remedy for POI took shape in 2008, when Fu et al

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Adenosine monophosphate-activated protein kinase (AMPK) is a key prospective target of metformin since it serves as a cellular energy sensor that becomes activated in response to metabolic stress, leading to improved glucose uptake (50)

Of the 24 proteins differentially expressed in kidney tissue, a total of seven proteins were validated by Western blot analysis

Williams et al., 2025

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