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2019;18(1):e12876

With aging, there is a progressive loss of motor neurons, leading to muscle fiber denervation and fragmentation of the NMJ, which profoundly impairs efficient neurotransmission ( Mitochondrial dysfunction and oxidative stress, both prominent features of muscle aging and sarcopenia, have been shown to directly damage components of the NMJ (Sun et al., 2024)

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Many older adults dont get enough B12 even with a seemingly normal diet

Tiano et al., 2011)

Suppression of Glucagon Secretion: Decreased glucagon reduces hepatic gluconeogenesis and glycogenolysis