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Get Started Sources University of Maryland Medical Centre, 2002 Stephens, F.B., Constantin-Teodosiu, D., and Greenhaff, P.L., New insights concerning the role of carnitine in the regulation of fule metabolism in skeletal muscle, J

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Concretely, lactylation of PDHA1 at K336 and CPT2 at K457/8 results in the inactivation of both enzymes and the inhibition of OXPHOS by restricting acetyl-CoA influx from pyruvate and fatty acid oxidation, respectively

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