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Although topical HQ has been prohibited in some countries, there is no substantial evidence of risk from topical use for treatment of melasma

Interestingly, of the combined phospho-sites identified by us and others, S155, T189, T230, S246 and S284 are known phosphorylation sites in mammalian ArfGAP1 according to the PhosphoSitePlus database, whereas intriguingly T291 rather than T292 is also a known phosphorylation site

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Hernanz A, De la Fuente M, Navarro M, Frank A

FIGURE 2 Targeting various RCD pathways to treat cancer has been under intensive investigation for several decades (Peng et al., 2022)