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Reviewer 2 The manuscript provides a good overview of the functions of glucose and ketones in metabolism, but often lacks arguments to back up the opinion statements The authors submitted an opinion piece on ketone bodies supporting glucose as an alternative energy fuel in the brain

A clinical study on glutathione supplementation in healthy adults documented improved markers of aerobic metabolism and reduced exercise-induced oxidative damage after 2-4 weeks of supplementation (Aoi et al., 2015)

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10.1016/j.bcmd.2012.10.006 139

This strategy has been exploited in the long-acting GLP-1RA semaglutide (Novo Nordisk), for instance, which was approved for treatment of T2DM in 2017, and for treatment of obesity in 2021, and has since then become the most prescribed GLP-1RA 92

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