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Unlike peptides synthesized through traditional cellular pathways, MOTS-c originates from a unique source and exerts its influence through a powerful metabolic pathway, establishing a new paradigm in cellular communication and regulation

Journal of Physiology-Paris 87:313327 Sikiric P, Rucman R, Turkovic B, Sever M, Klicek R, Radic B, Drmic D, Stupnisek M, Misic M, Vuletic LB, Pavlov KH (2018) Novel cytoprotective mediator, stable gastric pentadecapeptide BPC 157

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Finally, BPC 157 markedly improves the healing of traumatic nerve (18) and traumatic brain injury (19) and ameliorates encephalopathies that occur in severely intoxicated animals (20-23) and therefore, exhibits particular neuroprotective ability

38,238,243 Besides, the oscillation activation of SIRT1 also regulates the circadian dynamics via deacetylation of the core clock repressor PER2 K680 and mixed-lineage leukemia 1 (MLL1), thereby controlling rhythmic chromatin property and the activity of BMAL1: CLOCK complex