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Shotgun metagenomics reveals metabolic potential and functional diversity of microbial communities of Chitu and Shala soda lakes in Ethiopia

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6.2 Discussion and future perspectives translating SAR insights into rational drug design To bridge the translational gap between preclinical promise and clinical efficacy in sepsis management, future research paradigms must decisively pivot from the empirical screening of crude extracts toward SAR-guided lead compound optimization and targeted delivery