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In aged human lenses, vitamin C levels are greatly decreased and thus may fail to protect the lenses against oxidative stress-induced cataracts (37)

found that metformin demonstrated significant improvement in knee pain among overweight or obese OA patients in a randomised controlled trial

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Similarly, OVE26 mice exhibited glomerular basement membrane thickening, podocyte apoptosis, foot process effacement and podocyte loss (Fan et al., 2015)