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PI3K signaling influences the formation and turnover of the actin cytoskeleton, and by affecting actin polymerization and depolymerization, it can facilitate the formation of lamellipodia and filopodia at the leading edge and affect the retraction of the rear of the cell during migration [106]

In the absence of vascular anastomosis during ovarian tissue transplantation (72), the blood and oxygen supply primarily relies on the neovascularization within the transplanted ovarian tissue