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However, proliferation was elevated solely under rotational stress and was inhibited in the combined model

REGULATORY MECHANISMS OF NRF2 ACTIVITY Keap1 was identified as a cytoplasmic Nrf2-interacting protein that negatively regulates Nrf2 activity (Wakabayashi et al., 2003)

[DOI] [PubMed] [Google Scholar] 26.Duranton F, Cohen G, De Smet R, et al

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The central regulator of the ARE-response is the transcription factor Nrf2, which on stimulation dissociates from its cytoplasmic inhibitor Keap1, translocates to the nucleus and transactivates ARE-dependent genes