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In addition, a single dose of glutamine increases absolute T cell count (CD3+) and the count of CD8+ T cells but produces no effect on NK/neutrophils, CD4+/CD8+ ratio, or CD19+ lymphocytes [73]

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Even if a fraction of the active ingredient reaches the small intestine intact, its absorption is often severely restricted due to unfavorable molecular size, poor intestinal permeability, and extensive hepatic first-pass metabolism