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GPx are involved in the glutathione oxidation-reduction (redox) cycle ( Figure 1 )

10.1111/j.1471-4159.2009.06040.x J

Activation of the autophagy initiation signal AMPK and inhibition of mTOR both mitigate the onset of ferroptosis [114, 115]

SIRT2, the primary sirtuin localized in the cytoplasm, shows decreased expression during the transition from mitochondrial OXPHOS to glycolysis when cells transform into cancer cells