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[9] It may often go unrecognized, as the body becomes used to feeling unwell

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This in part explains their eagerness to have Kennedy help them make these substances available again

Nevertheless, emerging data allow us to propose that severe hyperhomocysteinemia might primarily have homocysteinylation effects related to homocysteine and/or its by-products (as homocysteine thiolactone) that would affect the vascular wall structure through a mechanism independent of an oxidant stress