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MTHFR, Hashimoto's, and Nutrients Dr. Izabella Wentz The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases PMC It's scary finding out that you, or your kids, have a MTHFR variant. I freaked out when I learned that I have the MTHFR compound heterozygous 677 and 1298 variant. This variant MTHFR 677 C>T Polymorphism Reveals Functional Importance for 5 Methyltetrahydrofolate, Not Homocysteine, in Regulation of Vascular Redox State and Endothelial Function in Human Atherosclerosis Circulation Converging Evolutionary, Environmental and Clinical Ideas on Folate Metabolism MTHFR Gene Mutations Explained: Symptoms, Risks & Testing Guide

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