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Type I IFNs Type I IFNs include IFN-, IFN-, and several other IFNs that interact with IFNAR1 and IFNAR2 to activate a range of IFN-stimulated genes via STAT1 and STAT2 signaling (243, 244)

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pharmacokinetic and brain-biodistribution studies will be needed to establish in-vivo comparability and therapeutic margins

In this review, recent progress in research on APX, GR and stress tolerance will be discussed

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