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The reviewer SD declared a shared affiliation, though no other collaboration, with several of the authors AH, CB, FM, and FMo to the handling Editor

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Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals

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This also results in the reduced production of intrinsic factor which can then interfere with vitamin B12 absorption