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doi: 10.3389/fbioe.2026.1751293 Received 21 November 2025 Revised 11 January 2026 Accepted 18 February 2026 Published 12 March 2026 Volume 14 - 2026 Edited by Yaying Sun, Shanghai General Hospital, China Reviewed by Yushu Wang, Tufts University, United States Yibo Ma, Second Affiliated Hospital of Dalian Medical University, China Updates Copyright 2026 You, Liu, Zhang, Zheng, Dou, Yao, Li, Wang and Huang

Gui DY, Lewis CA, Vander Heiden MG (2013) Allosteric regulation of PKM2 allows cellular adaptation to different physiological states

Increased oxidative stress in sarcoidosis is known to be associated with clinical outcomes such as alveolar epithelial damage and fibrosis, PON1 deficiency may facilitate the pulmonary effects of sarcoidosis

He frames it as a molecule that sits at the center of how cells function, particularly in relation to energy production and long-term cellular performance