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Neurons are highly susceptible to oxidative stress due to their high metabolic rate and limited regenerative capacity, leading to apoptosis via mitochondrial dysfunction and cytochrome C release (Zufferey et al., 2025)

falciparum ( R539T and Cam3.II C580Y strains show significantly higher amounts of glutathione and glutamylcysteine (glutathione precursor) compared with sensible strains (Siddiqui et al., 2017)

[DOI] [PubMed] [Google Scholar] [116].Lei XG, Cheng WH, McClung JP, Metabolic regulation and function of glutathione peroxidase-1

In this scenario, MODA co-administration resulted in a significant reduction in this ANT-induced Bcl-2 expression, bringing it back to levels comparable with normal controls

Q.J130000.3851.18J88

This strain has been extensively studied in murine tumor models and has demonstrated specific tumor-targeting capabilities and tumor-suppressive effects