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Case reports and safety reviews have linked Lcarnitine with new seizures or increased seizure frequency in some susceptible individuals

However, higher doses may carry the risk of other adverse effects, including agitation and activation

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Published epidemiological studies have indicated that children exposed to valproate in utero have lower cognitive test scores than children exposed in utero to either another antiepileptic drug or to no antiepileptic drugs

In the initial model, brief intracerebroventricular pulsed infusions of propionic acid into adult animals produced reversible (~30 min) bouts of ASD-type behaviors including altered social interactions (193), stereotyped behavior (194), tics (194), and hyperactivity (194, 195) as well as other cognitive and sensorimotor deficits (196) [see Fig

It may also have antioxidant activity