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Wolfe and Cyr, 2011) collectively referred to as amyloidosis (Metkar et al., 2024) Tau proteins representing the characteristic pathology of Alzheimers disease (Chen and Yu, 2023) are normally associated with stabilization of neuronal microtubules (Jesu et al., 2004), but give rise to fibrillar tangles along with -amyloid under a hyperphosphorylated state

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A 2018 systematic review and meta-analysis identified 20 randomized controlled trials (published between 2007 and 2017) that examined the effect of supplemental lipoic acid on markers of glucose utilization in 1,245 subjects with metabolic disorders (not limited to type 2 diabetes) (60)

Under the same conditions, treatment with the current drug of choice, PZQ, or the clinically tested and now discontinued meclonazepam (MZM) 42 , which have different schistosomicidal mechanisms and do not inhibit TGR, resulted in no change of that ratio

For more lasting changes (especially with skin tone or detox), a series of treatments over several weeks is typically recommended