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Weight loss, improved insulin sensitivity and reduced systemic inflammation may improve disease severity in some patients

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Guant JL, Guant-Rodriguez RM, Alpers DH

This personalized approach maximizes treatment benefits while maintaining safety standards

Within the SELECT population with BMI 30 kg m 2 or 27 kg m 2 with at least one obesity-related comorbidity, the mean weight loss was 14.9% at week 68, compared with 2.4% with placebo 14

It is important to recognise that vitamin B12 is water-soluble, and the body has limited capacity to absorb large doses in a single sitting