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Cell 184 , 12991313.e1219 (2021)

Stromal interaction molecule 1 (STIM1) detects ER calcium depletion, translocates to ER-plasma membrane junctions, and activates Ca 2+ release-activated channels (CRAC) by tethering Orai proteins, triggering CaMKK activation, which phosphorylates AMPK at Thr172

Aug 2013;23(3):273-285

In addition, DIM may activate Nrf2, a key cellular signaling pathway that regulates antioxidant activity and detoxification

TASK-3 channels are widely distributed in several brain regions, such as the hippocampus, cortex, and cerebellum, as well as in specific nuclei, including the locus coeruleus, paraventricular nucleus of the thalamus, and dorsal raphe nucleus (Talley et al., 2001)