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Treatment involves nonpharmacologic approaches (e.g., olfactory training, cognitive rehabilitation, and physical therapy) and pharmacologic agents (e.g., gabapentinoids, tricyclic antidepressants, and experimental treatments such as N -acetylcysteine and guanfacine)

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This work was supported by the National Key Research and Development Program of China (2020YFA0908400 to S.W.), the Distinguished Young Scholars of Hubei Province (2022CFA078 to S.W.), the Knowledge Innovation Program of Wuhan-Shugung Project (2023020201020418 to S.W.), the Young-Thousands Talents Program and the National Natural Science Foundation of China (32371344 to H.R.), as well as the startup funding from LSI, Zhejiang Key Laboratory of Molecular Cancer Biology at Zhejiang University

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and gut-barrier signalling

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