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Insufficient autophagy inhibits Nrf2-mediated antioxidant defenses, promoting iron deposition and LPO, leading to ferroptosis (Peng et al., 2022)

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Liproxstatin-1 maintains the integrity of the blood-spinal barrier by upregulating the expression of tight junction proteins and reduces ferroptosis in endothelial cells by upregulating GPX4 and downregulating ACSL4 and ALOX5