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(2018) demonstrated that dysregulation of downstream Rab substrates of LRRK2 resulted in neurodegeneration of dopaminergic neurons in the mammalian brain

As each approach targets only one aspect of the underlying pathophysiology, a single mechanism is unlikely to achieve optimal clearance

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Muscle fiber necroptosis in pathophysiology of idiopathic inflammatory myopathies and its potential as target of novel treatment strategy

Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects