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Despite considerable progress in the field of psychopharmacology, traditional antidepressant therapies persistently exhibit significant shortcomings, such as delayed therapeutic onset, suboptimal rates of remission, elevated instances of partial response, and adverse side-effect profiles (2, 3)

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In depression specifically, multiple randomized studies support L-methylfolate as an effective adjunct for SSRI-resistant cases

1992;12(5-6):243246 PMID:1284499 13

CoQ10 is the essential shuttle that moves electrons through the mitochondrial electron transport chain to generate adenosine triphosphate (ATP), the primary energy currency of the human body