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Because FMRP regulates the expression and function of numerous neuronal genes [151, 152], these results further suggest that in PD, DA neuron dysfunction is likely to be present long before morphological and histopathological changes and that the loss of FMRP in the SNc may be a key molecular event in these stages (Fig

Figure 2: T Red structures designate CVOs50

Also, in type 2 diabetes mellitus patients, impaired zinc homeostasis leads to uncontrolled expression of immune mediators, such as IL-1, IL-6, and NF-B, which at the same time simultaneously exacerbate the immune response and lead to pathogenesis, negatively affecting -cells

doi: 10.1016/j.intimp.2023.111236 37 HooperA.ParachaR.MaguireJ

Clin Cancer Res (2014) 20:19902000

High glucose levels boost the aggressiveness of highly metastatic cholangiocarcinoma cells via O-GlcNAcylation