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RHEB activation of mTORC1 on the membrane Using symmetry expansion and particle subtraction to remove RAPTORRAGRagulator, we performed 3D classification on the subpopulation that does not contain extra RAGRagulator copies and identified two distinct conformations of the mTORRHEBMLST8 subcomplex

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2c): OCD (with normally distributed OCI): Pearsons r = 0.40, p = 0.01, p -FDR = 0.05, and healthy volunteers (with non-parametrically distributed OCI): Spearmans r = 0.44, p = 0.01, p -FDR = 0.02)

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Autophagy and neurodegeneration: pathogenic mechanisms and therapeutic opportunities

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