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PPP is associated with increased cancer cell survival and proliferation (74, 77), implying the inhibition of phosphofructokinase (mainly PFK1) from glycolysis (78, 79), a direct competitor of glucose-6-phosphate dehydrogenase (G6PD), the limiting enzyme in PPP (75)

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On the other hand, non-pharmacological interventions like physical therapy improve mobility with potential muscle soreness, while speech and occupational therapy target speech and daily living challenges with minimal adverse effects

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