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The recommended dose of ALIMTA when administered with cisplatin for initial treatment of locally advanced or metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m2 as an intravenous infusion over 10 minutes administered prior to cisplatin on Day 1 of each 21-day cycle for up to six cycles in the absence of disease progression or unacceptable toxicity

Carducci, E

Targeting these mitochondrial dependencies has emerged as a promising therapeutic strategy in CRc [6]

Additionally, mitochondrial defects contribute to increased ROS levels and decreased ATP production, which is vital for maintaining cellular homeostasis, particularly in energy demanding cells like RGCs (127)