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Indeed, plasma metabolite profiling studies have uncovered new mechanistic insights for several diseases [134, 135]

GATA4 directly binds to gene promoters to enhance transcriptional activation of angiogenic factors VEGFA and VEGFC (Jia et al., 2018)

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Therefore, future research should focus on clarifying the doseresponse relationship, particularly in contexts such as functional foods, pediatric applications, and chronic disease management, to establish scientifically grounded and rational dosage recommendations

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