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Images were acquired using a confocal microscopy (TCS SP8 AOBS, Leica Microsystems GmbH, Wetzlar, Germany, or Nikon D-Eclipse C1, Nikon Corporation, Tokyo, Japan) and processed with Fiji-ImageJ software (version 2.3.0/1.53q)

When GPx3 was correlated to age, we also found a poor correlation exists between these two variables (Pearson correlation coefficient (r) = 0.17, p = 0.02), indicating that age is not strongly influencing the differences of GPx3 abundance in this sibling cohort (Supplementary Fig