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Navarro, P

Overexpressed IGFBP-1 in transgenic mice shows that its increase produces hyperinsulinaemia accompanied by glucose intolerance, and that this process is dependent upon IGFBP-1 phosphorylation statewhich is increased in diabetes [259]

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Data availability The datasets generated and/or analysed during the current study are not publicly available as per the rules and regulations of the Research Center for Biochemistry and Nutrition in Metabolic Diseases at the Kashan University of Medical Science but are available upon reasonable request from the corresponding author

In order to reach the systemic circulation after oral administration, these drugs have to overcome numerous barriers including the enzymatic, sulfhydryl, mucus and epithelial barrier. 7 Are peptide nasal sprays effective

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