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This copper-dependent form of cell death is known as cuproptosis ( 2+ enters the mitochondrial compartment of cells, FDX1 reduces Cu 2+ to Cu + , resulting in the oligomerization of DLAT protein and the downregulation of Fe-S cluster protein expression

Christensen JG, Zou HY, Arango ME, Li Q, Lee JH, McDonnell SR, Yamazaki S, Alton GR, Mroczkowski B, Los G

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TCA Cycle Disruption and Epigenetic Alterations: HIV-induced mitochondrial stress reduces metabolites such as acetyl-CoA and -ketoglutarate (-KG)

Nature Genetics 41, 2: 216-220

The antibody cDNA is then co-expressed with an amber suppressor tRNA and the properly paired mutant tRNA sythetase