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224 The lysine deacylase activity of SIRT4 is involved in the control of leucine metabolism and insulin secretion through regulating the acylation status of enzymes in these pathways

doi: 10.3389/fnins.2026.1731771 Received 24 October 2025 Revised 19 January 2026 Accepted 21 January 2026 Published 03 February 2026 Volume 20 - 2026 Edited by Heather Jane Mortiboys, The University of Sheffield, United Kingdom Reviewed by Abhishek Balmik, Emory University, United States Avital Schurr, University of Louisville, United States Updates Copyright 2026 Pang, Yang, Liu, Xie and Wang

In some embodiments, the heteroatom is selected from the group consisting of oxygen, nitrogen, and sulfur

Prior medications during hospitalization, patient stress and variable but unavoid-able delays between death and tissue procurement may also be confoundable variables

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We also observed a polarpolar interaction between CRBN Q178 and ENL Q41 (Fig