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Fe 3+ is taken up into cells in the form of ferritin through transferrin and transferrin receptor 1 and is then reduced to bivalent ferritin by the six-transmembrane epithelial antigen of prostate 3

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However, NPs usage has certain challenges, such as including ROS-induced toxicity, abnormal internalization into tissues, and aggregation

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doi: 10.3390/molecules26226945 Summary Keywords Parkinsons disease, neuroinflammation, T cells, microglia, neurodegeneration, animal models, inflammatory cascades Citation Grotemeyer A, McFleder RL, Wu J, Wischhusen J and Ip CW (2022) Neuroinflammation in Parkinsons Disease Putative Pathomechanisms and Targets for Disease-Modification