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10.1016/j.phymed.2020.153451 183 SilvaG

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The lack of Np63 expression in p53 wt breast cancer cells confirmed earlier reports and might be expected in p53 dom/neg MDD2 cells, as p53 regulated the level of Np63 through the Np63 promoter and transcriptional activation of AIP5 in cancer cells

Upregulation in phenylalanine (increased PAL), tyrosine (increased TYR, HPPD), arginine/proline (increased ARG, P5CR), and glycine/serine/threonine (increased AMT, TA) metabolism serves multiple protective functions: (1) Antioxidant Production: PAL activation promotes phenolic antioxidant synthesis