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At present, the use of FMT for long COVID remains experimental, as no formal regulatory guidelines have been established to support its clinical use in this context [160]

While it starts in the gut, researchers have found that its healing signals travel far beyond the digestive tract

Several laboratory studies have reported that UA has pro-inflammatory properties, including triggering the Akt/PRAS40 pathway, inducing IL-1 release, promoting ROS generation, and activating the toll-like receptor (TLR) 2/4 and NF-B signaling [48, 49]

Electronic supplementary material Supplementary Figures 122 Supplementary Note (download DOCX Synthetic procedures Supplementary Dataset 1 (download XLSX S-Sulfinylated cysteines identified and quantified in response to exogenous oxidants in A549 and HeLa cells as shown in Fig